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Arava contains active substance Leflunomide. Its active metabolite is A771726 inhibits dihydroorotate dehydrogenase and has antiproliferative effects. A771726 in vitro inhibits proliferation and DNA synthesis of T-lymphocytes induced by mitogen. A771726 selectively binds to dihydroorotate dehydrogenase and inhibits it and hereby G1 stage of lymphocytes proliferation. Lymphocyte proliferation is one of the crucial stages in the development of rheumatoid arthritis. Arava is used to treat rheumatoid arthritis and reduces inflammation in the joints.
Do not take Arava if you are under 18 years old, are allergic to leflunomide or any ingredients of the medication, are pregnant or breastfeeding, or if you have an impaired bone marrow function or other blood disorders, low levels of protein in the blood, impaired liver function, kidney function impairment, severe infections.
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