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The medications that may interact with Inspra are Lithium because the risk of its side effects may be increased by eplerenone; Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of eplerenone’s side effects; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease eplerenone’s effectiveness and increase the risk of high blood potassium levels and Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased.
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The medications that may interact with Inspra are Lithium because the risk of its side effects may be increased by eplerenone; Azole antifungals (eg, fluconazole, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin, troleandomycin ), nefazodone, protease inhibitors (eg, nelfinavir, ritonavir, saquinavir), or verapamil because they may increase the risk of eplerenone’s side effects; Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, naproxen) because they may decrease eplerenone’s effectiveness and increase the risk of high blood potassium levels and Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril), angiotensin-receptor blockers (eg, valsartan), potassium supplements, or potassium-sparing diuretics (eg, amiloride, spironolactone, triamterene) because the risk of high blood potassium levels may be increased.
Eplerenone (trade names include Inspra; Aldactone-EP; Eplenocard; Eptus; Exinia; Inspra-IC; Nonpres; Oldren; Planep; Selara; Suficard) is potassium-sparing diuretic (“water tablets” or “water pills”) medication from aldosterone antagonists pharmacological group. This medicine is used for the treatment of high blood pressure (hypertension), congestive heart failure, chronic heart failure, left ventricular dysfunction after a heart attack, central serous retinopathy (central serous chorioretinopathy). It reduces cardiovascular risk in people following myocardial infarction. Eplerenone works as aldosterone antagonists by blocking actions of the hormone aldosterone in the body.
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