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Tell your doctor if you have any medical conditions, and if you are taking any other medications, including non-prescription drugs from the supermarket, pharmacy or health food shops. Don’t stop taking Lyrica unless advised by your doctor. Tell your doctor if you become pregnant or are planning to become pregnant. For further information on the appropriate dose for your condition and if you are unsure or don’t understand the instructions on how to take your medicine, contact your doctor for help.
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Lyrica capsules and oral solution both contain the active ingredient pregabalin, which is a medicine that is used for three different purposes – treating epilepsy, nerve pain and anxiety. The way in which pregabalin works is not fully understood. It is thought to work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters from these nerve cells. Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. Pregabalin is thought to reduce the release of neurotransmitters called glutamate, noradrenaline and substance P. Glutamate is a neurotransmitter that acts as a natural ‘nerve-exciting’ agent. It is released when electrical signals build up in nerve cells and subsequently excites more nerve cells. It is thought to play a key role in causing epileptic seizures. Reducing the release of glutamate from the nerve cells in the brain is thought to help stabilise the electrical activity in the brain and prevent epileptic fits. Pregabalin is used as an add-on treatment for adults whose epilepsy has not been well controlled by other anti-epileptic medicines. It is used to prevent partial seizures, and partial seizures that spread to secondary generalised seizures. Glutamate, substance P and noradrenaline are also involved in transmitting pain signals in the brain and nervous system. As pregabalin reduces the release of these neurotransmitters it can also be used to treat nerve pain occuring as a result of damage to or a disturbance in the function of nerves (neuropathic pain). It can be used for peripheral neuropathic pain, ie nerve pain in the hands, legs or feet, or central neuropathic pain, eg as a result of a spinal cord injury. Pregabalin can also used to treat generalised anxiety disorder, which is another condition thought to involve overactivity of glutamate, substance P and noradrenaline in the brain.
Tell your doctor if you have any medical conditions, and if you are taking any other medications, including non-prescription drugs from the supermarket, pharmacy or health food shops. Don’t stop taking Lyrica unless advised by your doctor. Tell your doctor if you become pregnant or are planning to become pregnant. For further information on the appropriate dose for your condition and if you are unsure or don’t understand the instructions on how to take your medicine, contact your doctor for help.
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